Given the clinical significance of sarcopenia and the involvement of TP53 in muscle differentiation and homeostasis, the purpose of the present study was to investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism and to determine whether this polymorphism is associated with ASMMI in normal weight population (NW with a PBF < 30%), NWO, and preobese-obese (Preob-Ob) subjects, with PBF ≥ 30% [20–22]. This evidence concerns the gene TP53 and sarcopenia.