Considering the great interest toward p53 function in the context of skeletal muscle differentiation and apoptosis and the established difference in activities of Arg and Pro variants, we investigated the possible relationship between the polymorphism at codon 72 of p53 gene, body composition, and ASMMI in NW, NWO, and Preob-Ob women, to highlight a potential connection of these genetic variants with the predisposition to sarcopenia. The gene discussed is TP53; the disease is sarcopenia.