NGB and endothelial dysfunction: The reduced reactivity of LtHb both with respect to the nitrite reductase and nitrite anhydrase reactions relative to HbA suggests that under physiological conditions where NO levels are depleted as in endothelial dysfunction or in the event of NO scavenging LtHb as a possible HBOC may not be as effective as some PEGylated Hbs with respect to compensatory mechanism (35).