Another signal transmitter and activator of the transcription factor 3 [signal transducer and activator of transcription 3, (STAT3)] signaling pathway of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has also been studied for its involvement in tumor-associated signal transduction pathways (25–27). The gene discussed is TNFSF10; the disease is neoplasm.