In 2006, Gout et al (15) reported that DR3 expression in colon cancer tissue was higher than that in adjacent and normal colon tissues and that silencing the gene expression of DR3 reduced colon cancer HT29 cell adhesion and migration capacity, as well as weakened the metastatic potential of HT29 cells (16). Here, TNFRSF25 is linked to malignant colon neoplasm.