On the other hand, Murray et al. (1997) using immunostaining did not detect CYP1B1 protein in normal human skin (while in human skin cancer, there was strong immunoreactivity to anti-CYP1B1 antibodies of high specificity, which did not cross-react with CYP1A1 or CYP1A2). Here, CYP1B1 is linked to skin neoplasm.