The E2-activated targets comprised granulosa markers such as Hsd11b2 (Xu et al., 2011), but also some genes involved in cancer such as Tacc1, Angpt2, or Cbs (Ghayad et al., 2009, 1; Avraham et al., 2014; Weiner et al., 2012). The gene discussed is CBS; the disease is cancer.