We performed a comprehensive analysis of the available immunological and host genetics data, including HIV non-specific and HIV-specific ELISpot responses to the vaccine insert, CD4+ and CD8+ ICS responses to the vaccine insert, the vaccine vector and CMV, non-specific CD4+ and CD8+ T-cell activation, and HLA data with complete ascertainment of infections in Step and its long-term follow up study. This evidence concerns the gene CD4 and infection.