Here, our aim was to analyze a number of previously identified loci associated with SLE or with other autoimmune and/or inflammatory diseases (STAT4, IL10, IL23R, IRAK1, PSORS1C1, HCP5, MIR146a, PTPN2, ERAP1, ATG16L1, IRGM) in a sample of Italian SLE patients in order to confirm or verify their possible involvement and their relative contribution in SLE susceptibility. The gene discussed is IRGM; the disease is systemic lupus erythematosus.