They included the genes for immaturity expressed in the induced APL (1,782 probes, including 1,720 genes), the genes upregulated in promyelocyte differentiation not in the induced APL (447 probes, including 427 genes) and the genes specifically induced by PML-RARA (466 probes, including 429 genes) ((ii), (iii) and (iv) in the Materials and Methods). This evidence concerns the gene RARA and acute promyelocytic leukemia.