On the other hand, the genes related to neurotrophin signaling and the cell cycle, as well as those associated with metabolic processes, such as glycolysis/gluconeogenesis, the pentose phosphate pathway and sphingolipid metabolism were downregulated (Table S2), thus suggesting that the induced APL exhibited dysregulated signaling and metabolism as differentiated myeloid cells. The gene discussed is BDNF; the disease is acute promyelocytic leukemia.