However, in our exercise study of HIV uninfected subjects with no known cardiovascular disease we did show, for the first time to our knowledge, that HDLox correlated significantly with subendocardial viability ratio (SEVR), a noninvasive measure of subendocardial perfusion, C reactive protein (CRP) and oxidized Low Density Lipoprotein (ox-LDL) which is associated with the metabolic syndrome [58], [73]. The gene discussed is CRP; the disease is metabolic syndrome.