ADIPOR1 and chronic myelogenous leukemia, BCR-ABL1 positive: At later assays, K562 cells became 10-fold more sensitive to AdipoR agonist treatment either due to stress imposed by low nutrient media conditions, or due to the increased number of cell passages that potentially reflected the increased expression of AdipoR1 during CML pathogenesis (Ozturk et al., 2012).