ADIPOQ and cancer: Although some anti-diabetic drugs (e.g., metformin, a biguanide) (Hadad et al., 2008; Gonzalez-Angulo and Meric-Bernstam, 2010) as well as caloric restriction (Jiang et al., 2008) can partially mimic adiponectin action and induce AMPK (5′ adenosine monophosphate-activated protein kinase) signaling in cancer tissues, specific, and selective compounds targeting AdipoR were not available before 2011.