Against the K562 CML cell line which expresses low levels of ObR (Ozturk et al., 2012), however, Allo-aca either retains anti-proliferative activity without exogenous leptin added, or exhibits a narrower concentration window (approximately 100-fold) before it stimulates rather than inhibits cell growth depending upon the nutrient strength of the media or the cell passage (vide supra) (Otvos et al., 2014). Here, LEPR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.