LEP and chronic myelogenous leukemia, BCR-ABL1 positive: Against the K562 CML cell line which expresses low levels of ObR (Ozturk et al., 2012), however, Allo-aca either retains anti-proliferative activity without exogenous leptin added, or exhibits a narrower concentration window (approximately 100-fold) before it stimulates rather than inhibits cell growth depending upon the nutrient strength of the media or the cell passage (vide supra) (Otvos et al., 2014).