To explore these gaps, we assessed whether associations between variants presumed to lower VDR bioactivity or contribute to vitamin D insufficiency, and ovarian cancer risk differed by predicted 25(OH)D status in a retrospective case–control study (New England Case–Control study, NECC) and two case–control studies nested within the prospective Nurses’ Health Study (NHS) and NHSII cohorts. This evidence concerns the gene VDR and ovarian cancer.