Among women with high (above the median) predicted 25(OH)D levels, we observed significant increased risk of ovarian cancer associated with VDR variants rs731236 (per allele C OR = 1.31, 95% CI = 1.11–1.55; Ptrend = 0.002) and rs7975232 (per A allele OR = 1.38, 95% CI = 1.17–1.62; Ptrend = 0.0002; Table 4). This evidence concerns the gene VDR and ovarian carcinoma.