Subsequently, plasma levels of IL-6 and IL-2 were adjusted in multivariate analysis for other potential confounders, i.e., age, CIRS (comorbidity), ADL and IADL (functional abilities, activities of daily living, instrumental activities of daily living), HADS (hospital anxiety and depression), and pre-operative benzodiazepines intake. The gene discussed is IL6; the disease is depressive symptom measurement.