Independently of POD onset, high-plasma level of IL-6 was also associated with poor functional status or ADL <6 (p = 0.030), with cognitive decline or SPMSQ ≤7 (p = 0.014), emergency admission (p = 0.023), and higher comorbidity or CIRS ≥8 (p = 0.046). This evidence concerns the gene IL6 and Mental deterioration.