IL6 and metabolic disease: According to previous data (Bastard et al., 2000; Juge-Aubry et al., 2004; Aygun et al., 2005; Park et al., 2005), our results indicate that the induction of proinflammatory cytokines, IL-6 and TNF-α production, caused in PBMs stimulated by LPS, is similar to that observed in obese subject, where metabolic disorders, proinflammatory state and insulin resistance are often associated.