According to previous data (Bastard et al., 2000; Juge-Aubry et al., 2004; Aygun et al., 2005; Park et al., 2005), our results indicate that the induction of proinflammatory cytokines, IL-6 and TNF-α production, caused in PBMs stimulated by LPS, is similar to that observed in obese subject, where metabolic disorders, proinflammatory state and insulin resistance are often associated. This evidence concerns the gene TNF and Other metabolic disease.