For example, reelin expression is reduced approximately 50% in patients with schizophrenia (Impagnatiello et al., 1998; Berretta, 2012) and reelin haploinsufficiency in mice causes increased neuron packing density, decreased GAD67 levels, reduced pre-pulse inhibition and loss of dendritic spines, all features associated with schizophrenia pathology (Tueting et al., 1999; Liu et al., 2001). Here, RELN is linked to schizophrenia.