Dual specificity tyrosine-phosphorylation-regulated kinase 1A gain-of-function models have hippocampal-dependent cognitive alterations similar to those observed in Ts65Dn mice, the best characterized trisomic murine model for DS in which Dyrk1A is overexpressed, among other genes (reviewed in Sérégaza et al., 2006). Here, DYRK1A is linked to Dravet syndrome.