DYRK1A and Dravet syndrome: It is noteworthy that DYRK1A has been proposed as a candidate gene for some of the neuropathological phenotypes in DS, due to its location within HSA21, the fact that its protein product is overexpressed in DS individuals, and given that murine models overexpressing DYRK1A exhibit DS-like phenotypic alterations (Guimerà et al., 1996; Altafaj et al., 2001, 2013; Ahn et al., 2006; Dowjat et al., 2007; Guedj et al., 2009; Laguna et al., 2013).