BDNF and Huntington disease: In neuronal cells, in contrast to fibroblasts, the distances for cargo to be transported between the ER, Golgi and plasma membrane are extremely large and, therefore, a slight impairment in the efficiency of delivery is likely to result in major defects in protein secretion, which might contribute to the disease pathology associated with reduced BDNF secretion in HD (Wang et al., 2012; Zala et al., 2008; Pineda et al., 2009; Gauthier et al., 2004).