This is highly relevant because in a recently published manuscript (Andonegui et al. 2012), using an in vivo animal model, we have shown that IGF‐I plays a synergistic fibroproliferative role in lungs in the presence of TGF‐β1 Importantly, others have shown that patients with ALI/ARDS have elevated active TGF‐β1 levels in their lungs (Budinger et al. 2005). Here, TGFB1 is linked to acute respiratory distress syndrome.