In this study, we provide evidence of enhanced IGF‐I protein in the lungs of individuals with FP‐ARDS and provide further support for a role of IGF‐I in the fibroproliferative process by showing the induction and presence of IGF‐I in concert with enhanced levels of PCP III (a precursor of collagen III deposition) and collagen in the lungs. This evidence concerns the gene IGF1 and acute respiratory distress syndrome.