MUC4 and neoplasm: However, there were higher incidences of metastasis at different sites in the MUC4/Y-overexpressing group compared to the control groups (Figure 6C), including tumor spread in the spleen (6/8 vs. 4/7, P = 0.608), liver (7/8 vs. 3/7, P = 0.119), peritoneum (5/8 vs. 3/7, P = 0.619), mesenteric lymph nodes (5/8 vs. 2/7, P = 0.315), diaphragm (2/8 vs. 1/7, P = 1.000), intestinal wall (4/8 vs. 0/7, P = 0.026), and lung (6/8 vs. 1/7, P = 0.041), suggesting that MUC4/Y overexpression promoted tumor metastasis (intestinal wall) and distant metastasis (lung) significantly effectively.