Backward stepwise multivariate Cox analysis determined that tumor location (P = 0.001; HR: 2.452, 95% CI: 1.414-4.253), tumor differentiation (P <0.001; HR, moderate: 2.163, 95% CI: 0.994-4.706; HR, poor: 7.076, 95% CI: 2.655-18.857), TNM stage (P = 0.014; HR, IIA: 3.395, 95% CI: 1.414-8.148; HR, IIB: 3.551, 95% CI: 1.523-8.277; HR, III + IV: 4.218, 95% CI: 1.652-10.768), serum CA19-9 (P = 0.008; HR: 2.817, 95% CI: 1.313-6.043), and MUC4 expression (P = 0.010; HR: 1.976, 95% CI: 1.174-3.326) were significant independent risk factors. The gene discussed is MUC4; the disease is neoplasm.