Although we have pointed out the over-expression and alternative splicing of MUC4 may create a favorable environment for tumor progression by triggering malignancy-related positive feedback loops, it would be more expected to further investigate the interaction and network between those key mediators and their receptors, between involved signal pathways, as well as between transcription factors in the formation of circuit using new approaches like systems biology and clinical bioinformatics. Here, MUC4 is linked to neoplasm.