MUC4/Y not only up-regulates a series of genes (GLI family zinc finger 3, GLI3 [27]; bone morphogenetic protein 2, BMP2 [28]; wingless-type MMTV integration site family member 10B, WNT10B [29], IL8 [30], NGF [31]) related to the enhancement of cancer cell proliferation and increased transcription of apoptotic protein inhibitors (baculoviral IAP repeat containing 7, BIRC7 [32];), but also up-regulates glucose transporter (SLC2A1/GLUT1) related to the increased energy-generating ability. The gene discussed is CXCL8; the disease is cancer.