Additionally, the effects of MUC4/Y on ascending malignant abilities(proliferation, anti-apoptosis, motility, invasiveness, angiogenesis) of tumor cells can also affect the metastatic potential of pancreatic cancer cells during multi-steps of metastasis process, including invasion, intravasation, extravasation, metastatic colonization. This evidence concerns the gene MUC4 and pancreatic neoplasm.