Notably, our data provide evidence for MUC4/Y upregulates ITGB8 downstream of the actin cytoskeleton pathway (ITGB8-FAK-Cas/CrkII/DOCK180 complex-RAC- IRSp53- WAVE2-Arp2/3-F-Actin/PFN complex) to affect actin dynamics and cancer cell motility [33]. The gene discussed is CRK; the disease is cancer.