This GWAS meta-analysis of nearly 46,000 individuals identified several novel, suggestive candidate genes/regions for refractive astigmatism, including NRXN1, TOX and LINC00340. One of these regions, near the NRXN1 gene region, reached genome-wide significance in the White European adult group. This evidence concerns the gene NRXN1 and Astigmatism.