In this context, we have found that experimental up-regulation of miR-200c expression in bladder cancer cells leads to suppression of BMI-1 and E2F3, and disrupted invasion, migration and proliferation of the bladder cancer cells, whereas completely silencing miR-200c further up-regulates BMI-1 and E2F3 and promotes progression. Here, E2F3 is linked to urinary bladder carcinoma.