SPDEF and lung cancer: However, GRM4, RPS10, SPDEF, SCUBE3, and FKBP5 are, respectively, involved in the regulation of neural stem cell differentiation [21], mediation of mammary luminal epithelial lineage-specific gene expression [22], association with diamond-Blackfan anemia [23], regulation of early lung cancer angiogenesis and metastatic progression [24], and regulation of the immunosuppressive function of myeloid-derived suppressor cells [25].