NOTCH3 and ovarian serous adenocarcinoma: Retrovirus-mediated overexpression of the Notch3 intracellular domain (NICD3) in ovarian surface epithelium and low-grade serous ovarian cancer cell lines with low endogenous Notch3 levels led to upregulation of the stem cell associated genes Nanog and Oct4, further suggesting a role of the Notch pathway in CSC function [85].