PARP1 and ovarian serous adenocarcinoma: According to the results of phases 1 and 2 trials with PARP1 inhibitor Olaparib, BRCA mutation positive patients with platinum-sensitive relapsed serous ovarian cancer respond preferentially to PARP inhibition, with a significant reduction in risk of disease progression in comparison to patients with wild-type BRCA (Audeh et al. 2010; Fong et al. 2009, 2010; Ledermann et al. 2012, 2014).