SOX4’s role in bladder is perplexing: SOX4 is over expressed in bladder cancer tissues compared to normal tissues, but strong SOX4 expression was found to be correlated with increased patient survival (P <0.05) of bladder cancer [4], and when introduced to bladder cancer cell line HU609, it reduced cell viability by promoting apoptosis and necrosis [4]. The gene discussed is SOX4; the disease is urinary bladder cancer.