Given that the HDL-C is an intermediate in the causal pathway from the CETP gene to CAD, it would be sensible to conduct a meta-analysis that in some way integrates the triangle relationship: the TaqIB polymorphism-HDL-C (genotype-phenotype), the TaqIB polymorphism-CAD (genotype-disease), and HDL-C-CAD (phenotype-disease). This evidence concerns the gene CETP and coronary artery disorder.