Indeed, although HPV16 E6 and E7 proteins promote cell proliferation and survival by inactivating p53 and Rb tumour suppressor functions, conflicting data as to whether these viral products activate or repress NF-κB in cervical epithelial cells have been reported13, 14, 15, 16, 17, 18. The gene discussed is NFKB1; the disease is neoplasm.