As some Plexins bind and activate receptor tyrosine kinases (RTKs) such as MET, VEGFR2 and HER-2 to transmit Semaphorin-dependent signals in cancer cells47, 48, we next explored whether Semaphorin 3A triggers EGFR phosphorylation and, if so, whether KIAA1199 is required for this cross-talk. This evidence concerns the gene KDR and cancer.