As Plexin A2 deficiency enhanced Semaphorin 3A-dependent EGFR phosphorylations and also increased KIAA1199 protein levels, KIAA1199 acts as a pro-survival protein, at least by promoting EGFR signalling to limit Semaphorin 3A- and Plexin A2-mediated cell death in cervical cancer cells. Here, CEMIP is linked to cervical cancer.