Neuroblastoma cells were incubated with JNK inhibitor (SP600125; 20 μM) with metformin (10 mM) in presence of Rac1 inhibitor (NSC23766; 25 μM) or Cdc42 inhibitor (ML141; 10 μM), and cell viability was measured. This evidence concerns the gene RAC1 and neuroblastoma.