From 5501 patients under dapagliflozin 9 (0.16%) suffered from bladder cancer, whereas in the placebo group 1 of 3184 patients was affected (0.03%).21, 37 Reassuringly, no increase in bladder cancer was found subsequently with the other SGLT2 inhibitors, so that a chance finding is most likely.38 Carcinogenicity studies in animals were conducted with all SGLT2 inhibitors under development. Here, SLC5A2 is linked to urinary bladder cancer.