HMGB1 and diabetes mellitus: On the other hand, the association of HMGB1 with LC3 on capillaries and large blood vessels in DM and JDM suggests that HMGB1 may be involved in promoting angiogenesis and perfusion recovery, as recently demonstrated in cultured dermal microvascular endothelial cells and in the hind limb of a mouse ischemia model [42].