Based on what we mentioned above about the relevant relationship among TRPC6 expression, intracellular calcium homeostasis and the development of Pulmonary hypertension, it is reasonable to hypothesize that hypoxic calcium entry and cell proliferation in PV are potentially mediated via the TRPC–SOCE–[Ca2+]i signaling pathway. Here, TRPC6 is linked to pulmonary arterial hypertension.