NK cell response related genes such as CD247, KIR2DL4, KIR3DL1, KIR3DL3 and KLRB1 were down-regulated only in moderate and severe patients while genes such as KIR2DL1, KIR2DS4 and KIR3DL2 were down-regulated in all three groups of influenza patients (Figure 4). The gene discussed is KIR3DL3; the disease is influenza.