NOD2 and Cowden disease: Since the three NOD2 mutants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066845), and p.Leu1007fsX1008 (rs2066847) are the strongest genetic markers associated with the subsequent disease course in CD, we performed a genotype-phenotype correlation for the FOXO3A SNP rs12212067 in CD patients not carrying one of the three NOD2 mutations tested (table 4).