Considering the aim of our study, which tried to clarify the clinical value of the FOXO3A SNP rs122112067 for therapeutic decisions on an individual patient level, our data strongly suggest that - in contrast to the strong effect of NOD2 1007fs homozygosity – the FOXO3A SNP rs122112067 is not helpful for individual therapeutic decision given its very low predictive value for certain CD phenotypes. This evidence concerns the gene FOXO3 and Cowden disease.