STAT4 and hepatocellular carcinoma: Therefore, in this study, we mainly aimed to investigate the association of HLA-DP rs3077, rs9277535, HLA-DQ rs7453920 and STAT4 rs7574865 with HCC development, chronicity of HBV infection in Han population dwelling in West China, both from experiment and meta-analysis perspective to clarify the currently ambiguous role of these SNPs with HCC development, and to validate their correlations with HBV susceptibility and clearance from the experiment.