Similar to Efipladib (an inhibitor of fatty acid cleavage), Cerulenin (a fatty acid synthase inhibitor) decreased AKT phosphorylation at Ser473, enhanced antitumor activity of oxaliplatin in human colon cancer cells [31], and suppressed liver metastasis of colon cancer in mice [32]. The gene discussed is AKT1; the disease is malignant colon neoplasm.