Since Mcl-1 that can bind to and inhibit Noxa is also increased with melanoma progression [10, 24], and the ability of Noxa to trigger apoptosis is determined by a balance between its expression levels and the levels of Mcl-1 [37], it seems that high expression of Mcl-1 is sufficient to enable melanoma cells to withstand similarly high levels of Noxa. Here, PMAIP1 is linked to melanoma.