PMAIP1 and melanoma: While Noxa was not measurable in pooled melanocytes of three different lines (HEMa-LP, HEMn-DP, and HEMn-MP) by immunoblotting (pooled melanocytes were used to simplify analysis, as these melanocyte lines similarly did not express Noxa; Supplementary Figure S1), it was detected in all melanoma cell lines at various levels (Figure 1A).