Although the selective serotonin reuptake inhibitor, sertraline, was needed in a higher dose to prevent the PTZ, than the 4-AP-induced changes, the capability of sertraline to prevent the increase of IL-1β and TNF-α expression, accompanying the generalized tonic-clonic seizures induced by both, 4-AP and PTZ, was also clearly demonstrated in the present study. The gene discussed is TNF; the disease is Bilateral tonic-clonic seizure.