TNF and Bilateral tonic-clonic seizure: The single sertraline dose of 2.5 mg/kg given to the rat did not prevented the tonic-clonic seizures, and the rise in pro-inflammatory cytokines mRNA expression induced by PTZ, while the single sertraline dose of 25 mg/kg completely overcame the generalized tonic-clonic seizures as well as the increase in IL-1β and TNF-α mRNA expression induced by PTZ.