As shown in Table 2 and Figure 2, BDNF promoter methylation was significantly elevated in the AD cases as opposed to the controls (CpG1: p = 0.021; CpG2: p = 0.002; CpG3: p = 0.007; CpG4: p = 0.005; average methylation: p = 0.004). The gene discussed is BDNF; the disease is Alzheimer disease.