IHC score 3 showed distinct clinicopathologic features, and this MET overexpression group was significantly associated with older age (P = .005), larger tumor size (P = .009), invasion depth (P = .05), LN metastasis (P = .018), lymphatic invasion (P = .026), increased number of metastatic lymph nodes (P<.001), distant metastasis (P = .007), and higher TNM stage (P = .001). The gene discussed is MET; the disease is neoplasm.