In addition, the chemokine CXL12 and its target receptor CXCR4 which belongs to the large family of seven-transmembrane G-protein coupled receptors (GPCRs), have been found to be highly expressed in malignant pleural mesothelioma (MPM) cell lines and tumor tissues suggesting they can be involved in tumor progression and survival [2]. This evidence concerns the gene CXCR4 and neoplasm.