EZH2 and cancer: Because EZH2 is a target of miR-25 (Esposito et al., 2012), miR-26a (Sander et al., 2008), miR-30d (Esposito et al., 2012), miR-101 (Varambally et al., 2008), and miR-214 (Derfoul et al., 2011), downregulation of miR-25, miR-26a, miR-30d, miR-101, and miR-214 in human cancers are associated with EZH2 upregulation and malignant phenotypes.