Downregulation of anti-tumor (tumor suppressor) miR-125b in human cancers promotes survival, proliferation and invasion of tumor cells through de-repression of BCL2, BCL2L2, E2F3, ERBB2, FGFR2, MCL1, SIRT7, Smoothened and STAT3 (Figure 3B). This evidence concerns the gene E2F3 and cancer.