E2F3 and cancer: Because miR-195 is involved in repression of cell cycle accelerators (CCND1, CCNE1, CDK4, CDK6, and E2F3) and anti-apoptotic factors (BCL2, BCL2L2, and BIRC5) (Figure 3C), miR-195 functions as a tumor suppressor miRNA in various types of human cancers.