PRNP and Alzheimer disease: In this study, the binding of PrPC N1 and Aβ induced a conformational change that produced amorphous aggregates, the amount of PrPC N1 in guanidine hydrochloride extracts from insoluble amyloid deposits from AD brain was increased compared to non-demented controls, and there was a significant correlation between the amount of α-cleavage, which generates the N1 fragment, and duration of AD (Beland et al., 2014).