Moreover, PrPC expression is increased by heat shock, hypoxia, ischemia, hypoglycemia, stroke, and knockdown of any SOD protein while shutting down PrPC increases extracellular-SOD expression and SOD2 activity (Brown and Besinger, 1998; Shyu et al., 2000, 2004, 2005; McLennan et al., 2004; Mitsios et al., 2007; Kralovicova et al., 2009). Here, SOD1 is linked to Stroke.