For example, in a review by Hellemons et al. 13 relevant markers were found in the context of nephropathy in diabetes, of which five were found as significantly associated with onset as well as progression of DN again covering various mechanisms including inflammation (e.g., C-reactive protein), cell surface interaction and homeostasis (e.g., E-selectin, ICAM1) and metabolism (triglyceride levels) (Hellemons et al., 2012). This evidence concerns the gene SELE and kidney disorder.