Moreover, Jones et al. demonstrated that migration of MSCs to bone and bone marrow is CXCR4/SDF-1 dependent in a murine osteogenesis imperfecta model and that SDF-1 up-regulates CXCR4 demonstrating chemotaxis in vitro and enhancing engraftment in vivo (Jones et al., 2012). The gene discussed is CXCL12; the disease is osteogenesis imperfecta.