The recent identification of different genetic mutations such as parkin,α-synuclein and others has led to the development of genetic models of PD (Dawson et al., 2010); however, it is important to remember that, at most, only 10% of PD cases are due to genetic mutations (Dauer and Przedborski, 2003), while the majority of PD cases arise from unknown origins. The gene discussed is PRKN; the disease is Parkinson disease.