Differential methylation of the IGF2 gene, as well as other genes associated with T2DM, has been found to occur in children born to mothers experiencing famine, pointing to epigenetics as the mechanistic bridge connecting prenatal nutrition and the onset of T2DM later in life (Heijmans et al., 2007, 2008; Kaminsky et al., 2009; Tobi et al., 2009). This evidence concerns the gene IGF2 and type 2 diabetes mellitus.