OLFM4 and colorectal cancer: In a study on 176 colorectal cancer patients, those in which positive cytoplasmic immunohistochemical staining for OLFM4 was observed had better survival rates than those who showed negative staining, suggesting that OLFM4 could serve as a potential prognostic marker for long term survival of colorectal cancer patients (Seko et al., 2010).