The fact that overt hypothyroidism and even subclinical hypothyroidism have been associated with disorders of glucose and insulin metabolism [9,10] and that thyroid replacement therapy has been unable to restore Insulin Mediated Glucose Uptake (IMGU) to its physiological state suggests that molecular and cellular interactions other than the thyroid hormones are involved in the insulin resistance state [11]. The gene discussed is INS; the disease is hypothyroidism.