Different studies have reported a list of effective genes on osteoporosis; the most important of which are vitamin D receptor gene(VDR), estrogen receptor alpha (ESRα) ,interleukin -6 (IL-6), Collagen type I (COLIA1), LDL receptor-related protein 5 (LRP5) [26,42,43]. This evidence concerns the gene LRP5 and osteoporosis.