Dysfunction of Cdk5 is associated with a broad range of neurological disorders including neurodegenerative diseases such as Alzheimer’s Disease (AD) [8], Parkinson’s Disease (PD) [9], Amyotrophic Lateral Sclerosis (ALS) [10] and Huntington’s Disease (HD) [11], and brain disorders such as ischemia and stroke [12], epilepsy [13] and attention deficit disorders [14], among others. Here, CDK5 is linked to amyotrophic lateral sclerosis.